Lawesson's reagent → HCID 57642352, compound

HRID 2112503Notes

Reaction equation

HRID 2112503 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:27]#[N:28])[C:17]([O:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][O:25][CH3:26])=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:39])=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:27]#[N:28])[C:17]([O:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][O:25][CH3:26])=[CH:18][C:13]=2[NH:12][C:11](=[S:39])[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 57642377HCID 57642377, compound

Product 1

HCID 57642352HCID 57642352, compound

Procedure

5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-(2-(2-methoxyethoxy)ethoxy)-2H-1,4-benzodiazepin-2-thione (IIn) was prepared by reacting 0.00089 moles of 5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-(2-(2-methoxyethoxy)ethoxy)-2H-1,4-benzodiazepin-2-one (lactam In) with Lawesson's reagent in a manner analogous to Example 38. MH+/Z=430.

Sources & evidence

ORD record
ord-f4d414a75ff94248b1cd4711d9a0ba81
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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