Hydrazine → HCID 178486433, compound

HRID 2112512Notes

Reaction equation

HRID 2112512 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:21]#[N:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=2[NH:12][C:11](=S)[CH2:10][N:9]=1.CO[C:26](OC)([N:28](C)C)[CH3:27].[NH2:33]N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:21]#[N:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=2[N:12]=[C:11]2[NH:33][NH:28][C:26]([CH3:27])=[C:10]2[N:9]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642334HCID 57642334, compound

Product 1

HCID 178486433HCID 178486433, compound

Procedure

5-(2-chlorophenyl)-7-cyano-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVb) was prepared by reacting 0.0016 moles of 5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-methoxy-2H-1,4-benzodiazepin-2-thione (IIb) with 1,1-dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55. MH+/Z=364.

Sources & evidence

ORD record
ord-2712095a35ca40639e52e49a09dab9ae
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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