Hydrazine → 5-(2-chlorophenyl)-7-fluoro-8-(2-methoxyethoxy)-3-methyl-1,2-dihydropyrazolo[3,4-b][1,4]benzodiazepine

HRID 2112513Notes

Reaction equation

HRID 2112513 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([F:24])[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[CH:18][C:13]=2[NH:12][C:11](=S)[CH2:10][N:9]=1.CO[C:28](OC)([N:30](C)C)[CH3:29].[NH2:35]N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([F:24])[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[CH:18][C:13]=2[N:12]=[C:11]2[NH:35][NH:30][C:28]([CH3:29])=[C:10]2[N:9]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642342HCID 57642342, compound

Product 1

HCID 1784960645-(2-chlorophenyl)-7-fluoro-8-(2-methoxyethoxy)-3-methyl-1,2-dihydropyrazolo[3,4-b][1,4]benzodiazepine

Procedure

5-(2-chlorophenyl)-1,2-dihydro-7-fluoro-8-methoxyethoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVf) was prepared by reacting 0.0026 moles of 5-(2-chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxyethoxy-2H-1,4-benzodiazepin-2-thione (IIf) with 1,1-dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55.

Sources & evidence

ORD record
ord-eb63a659aed24a43b17bc49aadb4965a
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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