Hydrazine → HCID 178421672, compound

HRID 2112516Notes

Reaction equation

HRID 2112516 reaction equation
[Br:1][C:2]1[C:3]([O:21][CH2:22][CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[CH:4][C:5]2[NH:11][C:10](=S)[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[C:6]=2[CH:20]=1.CO[C:33](OC)([N:35](C)C)[CH3:34].[NH2:40]N>>[Br:1][C:2]1[C:3]([O:21][CH2:22][CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[CH:4][C:5]2[N:11]=[C:10]3[NH:40][NH:35][C:33]([CH3:34])=[C:9]3[N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[C:6]=2[CH:20]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642362HCID 57642362, compound

Product 1

HCID 178421672HCID 178421672, compound

Procedure

7-bromo-5-(2-chlorophenyl)-1,2-dihydro-8-(3-(4-morpholinyl)propoxy)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVj) was prepared by reacting 0.0011 moles of 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-8-(3-(4-morpholinyl)propoxy)-2H-1,4-benzodiazepin-2-thione (IIj) with 1,1 -dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55. MH+/Z=530.

Sources & evidence

ORD record
ord-efcad135af26435d837d019a6ab4769f
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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