Hydrazine → HCID 178421675, compound

HRID 2112517Notes

Reaction equation

HRID 2112517 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:29]#[N:30])[C:17]([O:19][CH2:20][CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[CH:18][C:13]=2[NH:12][C:11](=S)[CH2:10][N:9]=1.CO[C:34](OC)([N:36](C)C)[CH3:35].[NH2:41]N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:29]#[N:30])[C:17]([O:19][CH2:20][CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[CH:18][C:13]=2[N:12]=[C:11]2[NH:41][NH:36][C:34]([CH3:35])=[C:10]2[N:9]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642390HCID 57642390, compound

Product 1

HCID 178421675HCID 178421675, compound

Procedure

5-(2-chlorophenyl)-7-cyano-1,2-dihydro-8-(3-(4-morpholinyl)propoxy)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVk) was prepared by reacting 0.00054 moles of 5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-(3-(4-morpholinyl)propoxy)-2H-1,4-benzodiazepin-2-thione (thiolactam IIk) with 1,1-dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55. MH+/Z=477.

Sources & evidence

ORD record
ord-951bb33006ae436fae183294428ec6de
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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