Hydrazine → HCID 178496063, compound

HRID 2112518Notes

Reaction equation

HRID 2112518 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:24]#[N:25])[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[CH:18][C:13]=2[NH:12][C:11](=S)[CH2:10][N:9]=1.CO[C:29](OC)([N:31](C)C)[CH3:30].[NH2:36]N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:24]#[N:25])[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[CH:18][C:13]=2[N:12]=[C:11]2[NH:36][NH:31][C:29]([CH3:30])=[C:10]2[N:9]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642359HCID 57642359, compound

Product 1

HCID 178496063HCID 178496063, compound

Procedure

5-(2-chlorophenyl)-7-cyano-1,2-dihydro-8-methoxyethoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVm) was prepared by reacting 0.00048 moles of 5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-methoxyethoxy-2H-1,4-benzodiazepin-2-thione (IIm) with 1,1-dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55.

Sources & evidence

ORD record
ord-404bfb29352540bbb34451a699889e50
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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