Hydrazine → HCID 178496234, compound

HRID 2112519Notes

Reaction equation

HRID 2112519 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:27]#[N:28])[C:17]([O:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][O:25][CH3:26])=[CH:18][C:13]=2[NH:12][C:11](=S)[CH2:10][N:9]=1.CO[C:32](OC)([N:34](C)C)[CH3:33].[NH2:39]N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:27]#[N:28])[C:17]([O:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][O:25][CH3:26])=[CH:18][C:13]=2[N:12]=[C:11]2[NH:39][NH:34][C:32]([CH3:33])=[C:10]2[N:9]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642352HCID 57642352, compound

Product 1

HCID 178496234HCID 178496234, compound

Procedure

5-(2-chlorophenyl)-7-cyano-1,2-dihydro-8-(2-(2-methoxyethoxy)ethoxy)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVn) was prepared by reacting 0.00067 moles of 5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-(2-(2-methoxyethoxy)ethoxy)-2H-1,4-benzodiazepin-2-thione (IIn) with 1,1-dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55. MH+/Z=452.

Sources & evidence

ORD record
ord-49d6390de3794a0e8f8094541c4de968
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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