Hydrazine → HCID 178495920, compound

HRID 2112520Notes

Reaction equation

HRID 2112520 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:28]#[N:29])[C:17]([O:19][CH2:20][CH2:21][N:22]([CH2:24][CH2:25][O:26][CH3:27])[CH3:23])=[CH:18][C:13]=2[NH:12][C:11](=S)[CH2:10][N:9]=1.CO[C:33](OC)([N:35](C)C)[CH3:34].[NH2:40]N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:28]#[N:29])[C:17]([O:19][CH2:20][CH2:21][N:22]([CH2:24][CH2:25][O:26][CH3:27])[CH3:23])=[CH:18][C:13]=2[N:12]=[C:11]2[NH:40][NH:35][C:33]([CH3:34])=[C:10]2[N:9]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642370HCID 57642370, compound

Product 1

HCID 178495920HCID 178495920, compound

Procedure

5-(2-chlorophenyl)-7-cyano-1,2-dihydro-8-(2-((2-methoxyethyl)methylamino)-ethoxy)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVv) was prepared by reacting 0.0005 moles of 5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-(2-((2-methoxyethyl)methylamino)-ethoxy)-2H-1,4-benzodiazepin-2-thione (IIv) with 1,1-dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55. MH+/Z=465.

Sources & evidence

ORD record
ord-527ac56c414542db97de3b8bc1ef2b4f
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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