Diisobutylaluminumhydride → HCID 178486510, compound

HRID 2112530Notes

Reaction equation

HRID 2112530 reaction equation
NC1C=C(OC)C(OC)=CC=1C(C1C=CC=CC=1OC)=O.NC1C(C)=NN(CC=C)C=1Cl.[CH3:33][O:34][C:35]1[C:36]([O:61][CH3:62])=[CH:37][C:38]2[N:44]=[C:43]3[N:45](CC=C)[NH:46][C:47]([CH3:48])=[C:42]3[N:41]=[C:40]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=3[O:58][CH3:59])[C:39]=2[CH:60]=1.[H-].C([Al+]CC(C)C)C(C)C>>[CH3:33][O:34][C:35]1[C:36]([O:61][CH3:62])=[CH:37][C:38]2[N:44]=[C:43]3[NH:45][NH:46][C:47]([CH3:48])=[C:42]3[N:41]=[C:40]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=3[O:58][CH3:59])[C:39]=2[CH:60]=1

Participants

5

Reactant 4

HCID 21225700DiisobutylaluminumhydrideHCID 57642319HCID 57642319, compoundHCID 576423441-Allyl-5-chloro-3-methyl-1H-pyrazol-4-amineHCID 178456655HCID 178456655, compound

Product 1

HCID 178486510HCID 178486510, compound

Procedure

1,2-dihydro-7,8-dimethoxy-5-(2-methoxyphenyl)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVaa) was prepared by reacting 0.0023 moles of (2-amino-4,5-dimethoxyphenyl)-(2-methoxyphenyl)-methanone (Xaa) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 1,2-dihydro-7,8-dimethoxy-5-(2-methoxyphenyl)-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine (XIVaa) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=365.

Sources & evidence

ORD record
ord-cf544af3723d454c83e7f288e4c16bad
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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