Hydrogen Peroxide → HCID 21474015, compound

HRID 2112558Notes

Reaction equation

HRID 2112558 reaction equation
[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:13])C(=O)[NH:6]2.[OH-:14].[Na+].OO>>[NH2:6][C:7]1[C:3]([C:4]([OH:13])=[O:14])=[C:2]([CH3:1])[C:10]([CH3:11])=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 2665354,5-Dimethylisatin

Product 1

HCID 21474015HCID 21474015, compound

Conditions

Temperature
85 °C

Procedure

An aqueous solution (80 ml) containing 4,5-dimethyl-1H-indole-2,3-dione (9.8 g, 0.056 mmol) and sodium hydroxide (8.1 g, 0.2 mol) was heated to 85° C., and then 10% aqueous hydrogen peroxide (43 ml) was slowly added. The obtained solution was stirred at 85° C. for 2 hours, cooled to room temperature, and filtered. The filtrate was adjusted to pH 1 using sulfuric acid, to obtain 6-amino-2,3-dimethylbenzoic acid as crystals.

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered

Sources & evidence

ORD record
ord-cf38bb236f604ab8b549d0b5a0bb910d
Source dataset
uspto-grants-2009_04
Patent number
US07524841B2

Reaction notes

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