m-Chloroperbenzoic acid → HCID 135829580, compound

HRID 2112559Notes

Reaction equation

HRID 2112559 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[C:18]([S:23][CH3:24])[NH:17][C:16]2=[O:25]>ClCCl>[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[C:18]([S:23]([CH3:24])=[O:9])[NH:17][C:16]2=[O:25]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 135471382HCID 135471382, compound

Product 1

HCID 135829580HCID 135829580, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

m-Chloro-perbenzoic acid (3.3 g, 19 mmol) was added to a solution of 6-bromo-2-methylsulfanyl-3H-quinazolin-4-one (2.5 g, 9.2 mmol) in dichloromethane (200 ml), and the mixture was stirred at room temperature for 24 hours. The obtained solution was washed with an aqueous potassium carbonate solution and then concentrated, and the precipitated solid was filtered out and washed with aqueous hydrochloric acid to obtain 6-bromo-2-methylsulfinyl-3H-quinazolin-4-one.

Workup

  1. washThe obtained solution was washed with an aqueous potassium carbonate solution
  2. concentrationconcentrated
  3. filtrationthe precipitated solid was filtered out
  4. washwashed with aqueous hydrochloric acid

Sources & evidence

ORD record
ord-9e752b5150a94301b41529c7c73a858a
Source dataset
uspto-grants-2009_04
Patent number
US07524841B2

Reaction notes

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