Sodium Hydroxide → HCID 57642954, compound

HRID 2112774Notes

Reaction equation

HRID 2112774 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[C:15]3[CH:21]([CH3:22])[CH2:20][CH:19](Br)[C:18](=[O:24])[C:16]=3[S:17][C:11]=2[N:10]=[C:9]1[C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([O:33][CH3:34])=[C:27]([O:35][CH3:36])[C:26]=1[Br:37])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[C:15]3[C:21]([CH3:22])=[CH:20][CH:19]=[C:18]([OH:24])[C:16]=3[S:17][C:11]=2[N:10]=[C:9]1[C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([O:33][CH3:34])=[C:27]([O:35][CH3:36])[C:26]=1[Br:37])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57643014HCID 57643014, compound

Product 1

HCID 57642954HCID 57642954, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Benzyl-7-bromo-2-(2-bromo-3,4,5-trimethoxyphenyl)-5-methyl-6,7-dihydro-3H,5H-benzo[4,5]thieno[2,3-d]pyrimidine-4,8-dione (compound No. 685) (100 mg, 100 mol-%) and NaOH (20 mg, 400 mol-%) in 1.5 ml of ethanol was heated by using microwaves (100° C., 100 s). The solvent was evaporated. EtOAc was added and the reaction mixture was washed with 5% HCl-solution. The product was purified by chromatography using dichloromethane-EtOAc 9.5:0.5 as an eluent.

Workup

  1. custommicrowaves (100° C., 100 s)
  2. customThe solvent was evaporated
  3. additionEtOAc was added
  4. washthe reaction mixture was washed with 5% HCl-solution
  5. customThe product was purified by chromatography

Sources & evidence

ORD record
ord-f24383c7055d426cb1693c277f7f5a22
Source dataset
uspto-grants-2009_04
Patent number
US07524853B2

Reaction notes

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