Sodium Hydroxide → HCID 57642954, compound

Participants

Reaction Steps

3-Benzyl-7-bromo-2-(2-bromo-3,4,5-trimethoxyphenyl)-5-methyl-6,7-dihydro-3H,5H-benzo[4,5]thieno[2,3-d]pyrimidine-4,8-dione (compound No. 685) (100 mg, 100 mol-%) and NaOH (20 mg, 400 mol-%) in 1.5 ml of ethanol was heated by using microwaves (100° C., 100 s). The solvent was evaporated. EtOAc was added and the reaction mixture was washed with 5% HCl-solution. The product was purified by chromatography using dichloromethane-EtOAc 9.5:0.5 as an eluent.

Provenance & Evidence