Hydrochloric Acid → HCID 68854199, compound

HRID 2112844Notes

Reaction equation

HRID 2112844 reaction equation
[ClH:1].Cl.[N:3]1([CH2:9][CH:10]([C:20]2([OH:26])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH3:19])=[CH:13][CH:12]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.OC1(C(C2C=CC(C#CC)=CC=2)CN2CCN(C(OC(C)(C)C)=O)CC2)CCCCC1.Cl>>[ClH:1].[ClH:1].[N:3]1([CH2:9][CH:10]([C:20]2([OH:26])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:11]2[CH:16]=[CH:15][C:14]([C:17]#[C:18][CH3:19])=[CH:13][CH:12]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68851912HCID 68851912, compoundHCID 86599391HCID 86599391, compound

Product 1

HCID 68854199HCID 68854199, compound

Procedure

In an analogous manner to Example 135, step 4, 1-[2-piperazin-1-yl-1-(4-prop-1-ylphenyl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(4-prop-1-ynylphenyl)ethyl]piperazine-1-carboxylate. MS (ESI) m/z 327 ([M+H]+); HRMS: calcd for C21H30N2O.2.00 HCl, 398.1892; found (ESI), 327.2425.

Sources & evidence

ORD record
ord-9e8be6b56a2043f39a4abab3ebf5c1ed
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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