Tert-butyl 4-[2-(3-ethynylphenyl)-2-(1-hydroxycyclohexyl)ethyl]piperazine-1-carboxylate → HCID 86599398, compound

HRID 2112856Notes

Reaction equation

HRID 2112856 reaction equation
[ClH:1].Cl.C(C1C=C(C(N2CCNCC2)CC2(O)CCCCC2)C=CC=1)#C.[C:26]([C:28]1[CH:29]=[C:30]([CH:34]([C:49]2([OH:55])[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]2)[CH2:35][N:36]2[CH2:41][CH2:40][N:39](C(OC(C)(C)C)=O)[CH2:38][CH2:37]2)[CH:31]=[CH:32][CH:33]=1)#[CH:27]>>[ClH:1].[ClH:1].[C:26]([C:28]1[CH:29]=[C:30]([CH:34]([C:49]2([OH:55])[CH2:50][CH2:51][CH2:52][CH2:53][CH2:54]2)[CH2:35][N:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH:31]=[CH:32][CH:33]=1)#[CH:27]

Participants

3

Reactant 2

HCID 86599048Tert-butyl 4-[2-(3-ethynylphenyl)-2-(1-hydroxycyclohexyl)ethyl]piperazine-1-carboxylateHCID 86599399HCID 86599399, compound

Product 1

HCID 86599398HCID 86599398, compound

Procedure

In an analogous manner to Example 135, step 4, 1-[1-(3-ethynylphenyl-2-piperazin-1-ylethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-(3-ethynylphenyl)-2-(1-hydroxycyclohexyl)ethyl]piperazine-1-carboxylate. MS (ESI) m/z 313 ([M+H]+); HRMS: calcd for C20H28N2O+H, 313.2280; found (ESI, [M+H]+), 313.2280.

Sources & evidence

ORD record
ord-f4fe6f82a31147f6a80ecf38fabe2bfc
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

Loading…