HCID 68853654, compound → HCID 59701163, compound

HRID 2112867Notes

Reaction equation

HRID 2112867 reaction equation
Cl.Cl.[CH3:3][N:4]([CH3:29])[C@@H:5]1[CH2:9][CH2:8][N:7]([CH2:10][CH:11]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[CH2:6]1.Cl.Cl.N[C@@H]1CCN(CC(C2(O)CCCCC2)C2C3C(=CC=CC=3)C=CC=2)C1>>[CH3:29][N:4]([CH3:3])[C@@H:5]1[CH2:9][CH2:8][N:7]([CH2:10][CH:11]([C:22]2([OH:28])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]2)[C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[CH2:6]1

Participants

3

Reactant 2

HCID 68853654HCID 68853654, compoundHCID 68867680HCID 68867680, compound

Product 1

HCID 59701163HCID 59701163, compound

Procedure

In an analogous manner to Example 36, 1-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-1-(1-naphthyl)ethyl]cyclohexanol dihydrochloride was prepared from 1-[2-[(3R)-3-aminopyrrolidin-1-yl]-1-(1-naphthyl)ethyl]cyclohexanol (See Example 377). MS (ES) m/z 367.2; HRMS: calcd for C24H34N2O+H+, 367.27439; found (ESI, [M+H]+), 367.2735.

Sources & evidence

ORD record
ord-926148e610c040a18eff18df54992631
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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