Trifluoroacetic acid → HCID 86605131, compound

HRID 2112883Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[C:21]([Cl:23])[N:20]=[C:19]3[C:15]=2[N:16]([CH2:26][C:27]#[C:28][CH3:29])[C:17](=[O:25])[N:18]3[CH3:24])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[CH2:26]([N:16]1[C:15]2[C:19](=[N:20][C:21]([Cl:23])=[N:22][C:14]=2[N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:18]([CH3:24])[C:17]1=[O:25])[C:27]#[C:28][CH3:29]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57642844HCID 57642844, compound2×

Product 1

HCID 86605131HCID 86605131, compound

Procedure

4-[7-(2-Butynyl)-2-chloro-9-methyl-8-oxo-8,9-dihydro-7H-purin-6-yl]piperazine-1-carboxylic acid t-butyl ester (compound 1f) (15 mg) was dissolved in trifluoroacetic acid (1 mL). This reaction solution was stirred at room temperature for five minutes, and then concentrated. The residue was purified by reverse phase high performance liquid chromatography to give the title compound (11.07 mg).

Workup

concentrationconcentrated
customThe residue was purified by reverse phase high performance liquid chromatography

Sources & evidence

ORD record: ord-b63c3a19c4ed4671a185abf89cd16cb7
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07524847B2

Reaction notes

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