Water → HCID 178452261, compound

HRID 2112884Notes

Reaction equation

HRID 2112884 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13].C(N(CC)CC)C.O>C(#N)C>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:4]2[N:3]=[C:2]([Cl:1])[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][NH:8]3)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 53244122,6-Dichloropurine

Product 1

HCID 178452261HCID 178452261, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2,6-Dichloropurine [CAS No. 5451-40-1] (5.0 g) was dissolved in acetonitrile (70 mL), and then piperazine-1-carboxylic acid t-butyl ester (4.93 g) and triethylamine (4.1 mL) were added to this solution, and the reaction solution was stirred at room temperature for 22 hours. Water (200 mL) was added to the reaction solution, and this was stirred at room temperature for one hour, and then the white precipitate was collected by filtration. The white solid obtained was washed with water and hexane to give the title compound (8.5 g).

Workup

  1. stirringthis was stirred at room temperature for one hour
  2. filtrationthe white precipitate was collected by filtration
  3. customThe white solid obtained
  4. washwas washed with water and hexane

Sources & evidence

ORD record
ord-4b2f1cf53e404cb5b2a3d69b5d915c0c
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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