Trifluoroacetic acid → HCID 86605132, compound

HRID 2112888Notes

Reaction equation

HRID 2112888 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[C:21]([Cl:23])[N:20]=[C:19]3[C:15]=2[NH:16][C:17](=[O:25])[N:18]3[CH3:24])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[Cl:23][C:21]1[N:20]=[C:19]2[C:15]([NH:16][C:17](=[O:25])[N:18]2[CH3:24])=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:22]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57642818HCID 57642818, compound2×

Product 1

HCID 86605132HCID 86605132, compound

Procedure

4-(2-Chloro-9-methyl-8-oxo-8,9-dihydro-7H-purin-6-yl)piperazine-1-carboxylic acid t-butyl ester (compound 18d) (8 mg) was dissolved in trifluoroacetic acid. This reaction solution was stirred at room temperature for five minutes, and then concentrated. The residue was purified by reverse phase high performance liquid chromatography to give the title compound (5.08 mg).

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by reverse phase high performance liquid chromatography

Sources & evidence

ORD record
ord-148773259f124aadb3dac5e24f3ff31c
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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