Potassium Carbonate → HCID 57642835, compound

Participants

Reaction Steps

7-(2-Butynyl)-2,6-dichloro-7,9-dihydropurin-8-one (compound 1d) (193 mg) was dissolved in N,N-dimethylformamide (2 mL), and then 2,2-dimethylpropionic acid chloromethyl ester (163 μL) and anhydrous potassium carbonate (156 mg) were added to this solution. After stirring the reaction solution at room temperature for 18 hours, saturated aqueous ammonium chloride solution (5 mL) was added to the reaction solution. This was then extracted with ethyl acetate. The obtained organic layer was washed sequentially with water and then saturated brine, and then dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to give the title compound (434 mg).

Provenance & Evidence