Potassium Carbonate → HCID 57642835, compound

HRID 2112893Notes

Reaction equation

HRID 2112893 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[N:9][C:10]([Cl:15])=[N:11][C:12]=2[Cl:14])[NH:7][C:6]1=[O:16])[C:2]#[C:3][CH3:4].Cl[CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22].C(=O)([O-])[O-].[K+].[K+].[Cl-].[NH4+]>CN(C)C=O>[CH2:1]([N:5]1[C:13]2[C:8](=[N:9][C:10]([Cl:15])=[N:11][C:12]=2[Cl:14])[N:7]([CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[C:6]1=[O:16])[C:2]#[C:3][CH3:4]

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 25517Ammonium ChlorideHCID 87885Chloromethyl pivalateHCID 23085394HCID 23085394, compound2×

Product 1

HCID 57642835HCID 57642835, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7-(2-Butynyl)-2,6-dichloro-7,9-dihydropurin-8-one (compound 1d) (193 mg) was dissolved in N,N-dimethylformamide (2 mL), and then 2,2-dimethylpropionic acid chloromethyl ester (163 μL) and anhydrous potassium carbonate (156 mg) were added to this solution. After stirring the reaction solution at room temperature for 18 hours, saturated aqueous ammonium chloride solution (5 mL) was added to the reaction solution. This was then extracted with ethyl acetate. The obtained organic layer was washed sequentially with water and then saturated brine, and then dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to give the title compound (434 mg).

Workup

  1. extractionThis was then extracted with ethyl acetate
  2. washThe obtained organic layer was washed sequentially with water
  3. dry with materialsaturated brine, and then dried over anhydrous magnesium sulfate
  4. concentrationThe organic layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c442d00fb41a4a41a0c7c95b33390b49
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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