Trifluoroacetic acid → HCID 15605090, compound

HRID 2112900Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][N:20]=[C:19]3[C:15]=2[N:16]([CH2:32][C:33]#[C:34][CH3:35])[C:17](=[O:31])[N:18]3[C:23]2[CH:24]=[N:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>>[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39].[CH2:32]([N:16]1[C:15]2[C:19](=[N:20][CH:21]=[N:22][C:14]=2[N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:18]([C:23]2[CH:24]=[N:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=2)[C:17]1=[O:31])[C:33]#[C:34][CH3:35]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57642868HCID 57642868, compound

Product 1

HCID 15605090HCID 15605090, compound

Procedure

4-[7-(2-Butynyl)-9-(6-methoxy-pyridin-3-yl)-8-oxo-8,9-dihydro-7H-purin-6-yl]piperazi ne-1-carboxylic acid t-butyl ester (60 mg) was dissolved in trifluoroacetic acid, and this reaction solution was stirred at room temperature for five minutes, and then concentrated. The residue was purified by reverse phase high performance liquid chromatography to give the title compound (48.25 mg).

Workup

concentrationconcentrated
customThe residue was purified by reverse phase high performance liquid chromatography

Sources & evidence

ORD record: ord-413400b1424246fd9651589f70d25080
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07524847B2

Reaction notes

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