Trifluoroacetic acid → HCID 68827546, compound

HRID 2112902Notes

Reaction equation

HRID 2112902 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][N:20]=[C:19]3[C:15]=2[N:16]([CH2:24][C:25]#[C:26][CH3:27])[C:17](=[O:23])[NH:18]3)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[CH2:24]([N:16]1[C:15]2[C:19](=[N:20][CH:21]=[N:22][C:14]=2[N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[NH:18][C:17]1=[O:23])[C:25]#[C:26][CH3:27]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57642840HCID 57642840, compound2×

Product 1

HCID 68827546HCID 68827546, compound

Procedure

4-[7-(2-Butynyl)-8-oxo-8,9-dihydro-7H-purin-6-yl]piperazine-1-carboxylic acid t-butyl ester (compound 61e) (12 mg) was dissolved in trifluoroacetic acid. This reaction solution was stirred at room temperature for five minutes, and then concentrated. The residue was purified by reverse phase high performance liquid chromatography to give the title compound (8.86 mg).

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by reverse phase high performance liquid chromatography

Sources & evidence

ORD record
ord-cce7e992ac5047089da1151eaf1583c8
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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