Toluene → HCID 23085402, compound

HRID 2112918Notes

Reaction equation

HRID 2112918 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]3[N:20]([CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[C:21](=[O:32])[N:22]([CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[C:30]#[N:31])[C:18]=3[C:17]([O:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=3[C:47](=[O:49])[NH2:48])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C1(C)C=CC=CC=1.[F:57][C:58]([F:63])([F:62])[C:59]([OH:61])=[O:60]>ClCCl>[F:57][C:58]([F:63])([F:62])[C:59]([OH:61])=[O:60].[CH2:33]([N:20]1[C:19]2[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[N:15][CH:16]=[C:17]([O:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=3[C:47]([NH2:48])=[O:49])[C:18]=2[N:22]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]#[N:31])[C:21]1=[O:32])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 57642865HCID 57642865, compound

Product 1

HCID 23085402HCID 23085402, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[3-Benzyl-7-(2-carbamoylphenoxy)-1-(2-cyanobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4.5-c]pyridin-4-yl]-piperazine-1-carboxylic acid t-butyl ester (0.023 g) was dissolved in dichloromethane and trifluoroacetic acid (1 mL). After stirring this at room temperature for two hours, then toluene (5 mL) was added, and this was concentrated under reduced pressure. The residue was purified by reverse phase high performance liquid chromatography to give the title compound (0.016 g).

Workup

  1. concentrationthis was concentrated under reduced pressure
  2. customThe residue was purified by reverse phase high performance liquid chromatography

Sources & evidence

ORD record
ord-e759ed01d2e8455c94c726f09e27a1ce
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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