Ethylamine → N-Ethyl-2-{[(ethylamino)carbonyl]amino}-7-pyrimidin-5-yl[1,2,4]triazolo[1,5-a]pyridine-5-carboxamide

HRID 2112942Notes

Reaction equation

C([O:3][C:4]([C:6]1[N:11]2[N:12]=[C:13]([NH:15][C:16]([NH:18][CH2:19][CH3:20])=[O:17])[N:14]=[C:10]2[CH:9]=[C:8]([C:21]2[CH:22]=[N:23][CH:24]=[N:25][CH:26]=2)[CH:7]=1)=O)C.[CH2:27]([NH2:29])[CH3:28]>CC(N(C)C)=O>[CH2:27]([NH:29][C:4]([C:6]1[N:11]2[N:12]=[C:13]([NH:15][C:16]([NH:18][CH2:19][CH3:20])=[O:17])[N:14]=[C:10]2[CH:9]=[C:8]([C:21]2[CH:22]=[N:23][CH:24]=[N:25][CH:26]=2)[CH:7]=1)=[O:3])[CH3:28]

Participants

Conditions

Temperature: 60 °C

Procedure

A slurry of the product of Step 1 (0.268 g, 0.754 mmol) in dimethylacetamide (10 mL) was treated with ethylamine (2 mL, 30.6 mmol) then heated to 60° C. in a sealed tube for 16 h. The precipitate was filtered, washed with dimethylacetamide and then water, to give title compound as a solid; m.p. 317-321° C. ACPI-MS Found: [M+H]+=355.

Workup

filtrationThe precipitate was filtered
washwashed with dimethylacetamide

Sources & evidence

ORD record: ord-953176f3c8d4448fbb022465d9eb400f
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07524860B2

Reaction notes

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