Potassium Carbonate → N-Ethyl-N'-[5-(1,3-oxazol-5-yl)-7-pyridin-3-yl[1,2,4]triazolo[1,5-a]pyridin-2-yl]urea

Participants

Reaction Steps

A mixture of the product of Step 2 (40 mg, 0.13 mmol), tosylmethyl isocyanide (28 mg, 0.14 mmol) and K2CO3 (36 mg, 0.26 mmol) were stirred at room temperature in MeOH (5 mL) for a few minutes, then heated at reflux for 0.5 h. All solvent was then removed under reduced pressure, the residue taken up into MeOH/CH2Cl2, and dried onto silica. Purification was carried out by filtration through a plug of silica gel (5% MeOH/CH2Cl2 as eluant) to give the title compound as a solid. LCMS (APCI+) 350.

Provenance & Evidence