反应详情

A mixture of the product of Step 2 (40 mg, 0.13 mmol), tosylmethyl isocyanide (28 mg, 0.14 mmol) and K2CO3 (36 mg, 0.26 mmol) were stirred at room temperature in MeOH (5 mL) for a few minutes, then heated at reflux for 0.5 h. All solvent was then removed under reduced pressure, the residue taken up into MeOH/CH2Cl2, and dried onto silica. Purification was carried out by filtration through a plug of silica gel (5% MeOH/CH2Cl2 as eluant) to give the title compound as a solid. LCMS (APCI+) 350.

1. temperatureheated
2. temperatureat reflux for 0.5 h
3. customAll solvent was then removed under reduced pressure
4. customdried onto silica
5. customPurification
6. filtrationwas carried out by filtration through a plug of silica gel (5% MeOH/CH2Cl2 as eluant)