Acetic Anhydride → HCID 68835349, compound

HRID 2112945Notes

Reaction equation

HRID 2112945 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].C(N(CC)CC)C.[CH2:15]([NH:17][C:18]([NH:20][C:21]1[N:39]=[C:24]2[CH:25]=[C:26]([C:33]3[CH:34]=[N:35][CH:36]=[CH:37][CH:38]=3)[CH:27]=[C:28]([C:29]([NH:31][NH2:32])=[O:30])[N:23]2[N:22]=1)=[O:19])[CH3:16]>O1CCOCC1>[C:1]([NH:32][NH:31][C:29]([C:28]1[N:23]2[N:22]=[C:21]([NH:20][C:18]([NH:17][CH2:15][CH3:16])=[O:19])[N:39]=[C:24]2[CH:25]=[C:26]([C:33]2[CH:34]=[N:35][CH:36]=[CH:37][CH:38]=2)[CH:27]=1)=[O:30])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 68836444HCID 68836444, compound

Product 1

HCID 68835349HCID 68835349, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Acetic anhydride (0.95 mL, 10 mmol), triethylamine (1.2 mL, 8.6 mmol) and the product of Step 1 (0.996 g, 2.93 mmol) in dioxane (100 mL) was refluxed for 6 h. The solution was cooled and the product was filtered, washed with water and then dried to give 1-[5-(N′-acetyl-hydrazinocarbonyl)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-ethyl-urea as a solid ACPI-MS Found: [M+H]+=383.

Workup

  1. temperatureThe solution was cooled
  2. filtrationthe product was filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-369be15df4874f4db5b44e163eb8074c
Source dataset
uspto-grants-2009_04
Patent number
US07524860B2

Reaction notes

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