反应详情

To a stirring suspension of the product of Step 2, (0.88 g, 2.5 mmol) in THF (40 mL) and MeOH (5 mL) was added sodium borohydride (1.02 g, 27 mmol). After 1 h the reaction was quenched by the addition of ca. 50 mL water and stirred 1 h to allow formation of a precipitate. The solid was rinsed with water (3×10 mL) and dried in vacuo to give the alcohol, 1-ethyl-3-(5-hydroxymethyl-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-urea as a solid.

1. customAfter 1 h the reaction was quenched by the addition of ca. 50 mL water
2. washThe solid was rinsed with water (3×10 mL)
3. customdried in vacuo