HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 68835864, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (6-Methoxypyridin-3-yl)boronic acid | HCID 2734368 | — |
| Reactant | HCID 86618027 | HCID 86618027 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68835864 | HCID 68835864 | — |
Reaction Steps
To a mixture of 1-(5-chloro-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-3-ethyl-urea (0.2 g, 0.63 mmol) obtained in step 1, 6-Methoxy-pyridine-3-boronic acid (0.12 g, 0.78 mmol), and sodium carbonate (0.71 mL of a 2 M aqueous solution) in dioxane (6 mL) was added the catalyst Pd(dppf)Cl2 (30 mg, 5 mol %) and the resulting mixture was heated to reflux for 36 hours. The solvent was removed under reduced pressure. Purification using silica gel chromatography (2-10% MeOH/CHCl3) gave the title compound as a solid LCMS (APC+) 390.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524860B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-f9442e4387f44e32975383d77a5f22ea |
| Source note | uspto-grants-2009_04 |