HCID 68835224, compound → HCID 68839833, compound

HRID 2112979Notes

Reaction equation

HRID 2112979 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]3[N:20]=[C:21]([NH:23][C:24]([NH:26][CH2:27][CH3:28])=[O:25])[N:22]=[C:18]3[CH:17]=[C:16]([C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>C(Cl)Cl.C1(C)C=CC=CC=1>[CH2:27]([NH:26][C:24]([NH:23][C:21]1[N:22]=[C:18]2[CH:17]=[C:16]([C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[CH:15]=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[N:19]2[N:20]=1)=[O:25])[CH3:28]

Participants

4

Reactant 1

HCID 68835224HCID 68835224, compound2×

Product 1

HCID 68839833HCID 68839833, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

The product of Step 2, 4-[2-(3-ethyl-ureido)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-piperazine-1-carboxylic acid tert-butyl ester (0.52 g, 1.1 mmol) was suspended in CH2Cl2 (10 mL) Trifluoroacetic acid (5 ml) was added and the resulting solution was stirred at rt for 30 minutes. The reaction mixture was diluted with toluene and solvent was evaporated. The residue was purified by column chromatography on silica gel (0-10% MeOH in CH2Cl2 containing 1% NEt3 as eluant) to afford the target compound as a solid. MS (APCI+) 366 (M+1).

Workup

  1. additionwas added
  2. customwas evaporated
  3. customThe residue was purified by column chromatography on silica gel (0-10% MeOH in CH2Cl2 containing 1% NEt3 as eluant)

Sources & evidence

ORD record
ord-2da3f3cfba91441d9eb6449f4c5f5226
Source dataset
uspto-grants-2009_04
Patent number
US07524860B2

Reaction notes

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