[3-(Hydroxymethyl)phenyl]boronic acid → HCID 11559325, compound

HRID 2113038Notes

Reaction equation

HRID 2113038 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17](I)=[CH:16][CH:15]=2)[CH:7]=1)C.[OH:22][CH2:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1>>[OH:22][CH2:23][C:24]1[CH:29]=[C:28]([C:17]2[CH:16]=[CH:15][C:14]([O:13][CH2:12][C:8]3[CH:7]=[C:6]([CH2:5][C:4]([OH:3])=[O:21])[CH:11]=[CH:10][CH:9]=3)=[CH:19][CH:18]=2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2734662[3-(Hydroxymethyl)phenyl]boronic acidHCID 57643348HCID 57643348, compound2×

Product 1

HCID 11559325HCID 11559325, compound

Procedure

[3-(3′-Hydroxymethyl-biphenyl-4-yloxymethyl)-phenyl]-acetic acid was prepared using general procedure 5 from [3-(4-iodo-phenoxymethyl)-phenyl]-acetic acid ethyl ester (of intermediate 4) and 3-(hydroxymethyl)phenylboronic acid (available from Aldrich Chemical Company, Inc., Milwaukee, Wis.). Mass spectrum MH+=349.

Sources & evidence

ORD record
ord-5b8f7ba7f652453b85de8e0ed5c300a9
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

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