4,5,6,7-Tetrahydro-benzothiazole-2,6-diamine dihydrobromide → N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[6-methyl-2-oxo-3-(3-trifluoromethyl-phenylmethanesulfonylamino)-2H-pyridin-1-yl]-acetamide

HRID 2113056Notes

Reaction equation

HRID 2113056 reaction equation
[CH3:1][C:2]1[N:7]([CH2:8][C:9](O)=[O:10])[C:6](=[O:12])[C:5]([NH:13][S:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)(=[O:16])=[O:15])=[CH:4][CH:3]=1.Br.Br.[S:30]1[C:34]2[CH2:35][CH:36]([NH2:39])[CH2:37][CH2:38][C:33]=2[N:32]=[C:31]1[NH2:40]>>[NH2:40][C:31]1[S:30][C:34]2[CH2:35][CH:36]([NH:39][C:9](=[O:10])[CH2:8][N:7]3[C:2]([CH3:1])=[CH:3][CH:4]=[C:5]([NH:13][S:14]([CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:26])([F:25])[F:27])[CH:19]=4)(=[O:15])=[O:16])[C:6]3=[O:12])[CH2:37][CH2:38][C:33]=2[N:32]=1

Participants

3

Reactant 2

HCID 136706894,5,6,7-Tetrahydro-benzothiazole-2,6-diamine dihydrobromideHCID 576433722-[6-methyl-2-oxo-3-({[3-(trifluoromethyl)benzyl]sulfonyl}amino)-1(2H)-pyridinyl]acetic acid

Product 1

HCID 44339443N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[6-methyl-2-oxo-3-(3-trifluoromethyl-phenylmethanesulfonylamino)-2H-pyridin-1-yl]-acetamide

Procedure

The title compound was prepared from 2-[6-methyl-2-oxo-3-({[3-(trifluoromethyl)benzyl]sulfonyl}amino)-1(2H)-pyridinyl]acetic acid and 4,5,6,7-tetrahydro-1,3-benzothiazol-2,6-diamine dihydrobromide using the procedure of EXAMPLE 1 (STEP 6), and was obtained as a white solid compound.

Workup

  1. customwas obtained as a white solid compound

Sources & evidence

ORD record
ord-fa0fc867077a43799b03899a252bfc84
Source dataset
uspto-grants-2009_04
Patent number
US07524871B2

Reaction notes

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