Phenol → 5-[3-(2-Chloro-4-trifluoromethoxy-phenoxy)-propoxy]-2-methyl-2,3-dihydro-benzofuran-2-carboxylic acid

HRID 2113148Notes

Reaction equation

HRID 2113148 reaction equation
C[O:2][C:3]([C:5]1([CH3:15])[CH2:9][C:8]2[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:7]=2[O:6]1)=[O:4].C1(O)C=CC=CC=1.I[CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][C:35]([F:38])([F:37])[F:36])=[CH:30][C:29]=1[Cl:39]>>[Cl:39][C:29]1[CH:30]=[C:31]([O:34][C:35]([F:36])([F:38])[F:37])[CH:32]=[CH:33][C:28]=1[O:27][CH2:26][CH2:25][CH2:24][O:14][C:11]1[CH:12]=[CH:13][C:7]2[O:6][C:5]([CH3:15])([C:3]([OH:2])=[O:4])[CH2:9][C:8]=2[CH:10]=1

Participants

4

Reactant 3

HCID 996PhenolHCID 113562335-Hydroxy-2-methyl-2,3-dihydro-benzofuran-2-carboxylic acid methyl esterHCID 69053655Benzene, 2-chloro-1-(3-iodopropoxy)-4-(trifluoromethoxy)-

Product 1

HCID 104787635-[3-(2-Chloro-4-trifluoromethoxy-phenoxy)-propoxy]-2-methyl-2,3-dihydro-benzofuran-2-carboxylic acid

Procedure

The title compound was prepared following the general procedure described in Example 1, Step 4, using the the intermediate prepared in Example 1, Step 1 as the phenol and the iodide prepared in Step 2.

Sources & evidence

ORD record
ord-7d944248f43a4831870ba54082f3bf6b
Source dataset
uspto-grants-2009_04
Patent number
US07524882B2

Reaction notes

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