2-Ethyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester → 5-{3-[2-Chloro-4-(1,1-dimethyl-propyl)-phenoxy]-propoxy}-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid

HRID 2113153Notes

Reaction equation

HRID 2113153 reaction equation
C[O:2][C:3]([C:5]1([CH2:15][CH3:16])[CH2:9][C:8]2[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:7]=2[O:6]1)=[O:4].[Cl:17][C:18]1[CH:23]=[C:22]([C:24]([CH3:28])([CH3:27])[CH2:25][CH3:26])[CH:21]=[CH:20][C:19]=1[O:29][CH2:30][CH2:31][CH2:32]I>>[Cl:17][C:18]1[CH:23]=[C:22]([C:24]([CH3:27])([CH3:28])[CH2:25][CH3:26])[CH:21]=[CH:20][C:19]=1[O:29][CH2:30][CH2:31][CH2:32][O:14][C:11]1[CH:12]=[CH:13][C:7]2[O:6][C:5]([CH2:15][CH3:16])([C:3]([OH:2])=[O:4])[CH2:9][C:8]=2[CH:10]=1

Participants

3

Reactant 2

HCID 111603732-Ethyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl esterHCID 690536422-Chloro-1-(3-iodopropoxy)-4-(2-methylbutan-2-YL)benzene

Product 1

HCID 103889025-{3-[2-Chloro-4-(1,1-dimethyl-propyl)-phenoxy]-propoxy}-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid

Procedure

The title compound was prepared following the general procedure described in Example 1, Step 4 employing the phenol prepared in Example 4, Step 1 and the iodide prepared in Step 1.

Sources & evidence

ORD record
ord-8e98604b74c24357ac195c20eccf83d0
Source dataset
uspto-grants-2009_04
Patent number
US07524882B2

Reaction notes

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