2-Ethyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester → (2S)-5-{3-[2-Chloro-4-(2,2-dimethyl-propyl)-phenoxy]-propoxy}-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid

HRID 2113159Notes

Reaction equation

HRID 2113159 reaction equation
C[O:2][C:3]([C:5]1([CH2:15][CH3:16])[CH2:9][C:8]2[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:7]=2[O:6]1)=[O:4].[Cl:17][C:18]1[CH:23]=[C:22]([CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:21]=[CH:20][C:19]=1[O:29][CH2:30][CH2:31][CH2:32]I>>[Cl:17][C:18]1[CH:23]=[C:22]([CH2:24][C:25]([CH3:26])([CH3:28])[CH3:27])[CH:21]=[CH:20][C:19]=1[O:29][CH2:30][CH2:31][CH2:32][O:14][C:11]1[CH:12]=[CH:13][C:7]2[O:6][C@:5]([CH2:15][CH3:16])([C:3]([OH:2])=[O:4])[CH2:9][C:8]=2[CH:10]=1

Participants

3

Reactant 2

HCID 111603732-Ethyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl esterHCID 690498582-Chloro-4-(2,2-dimethylpropyl)-1-(3-iodopropoxy)benzene

Product 1

HCID 10343562(2S)-5-{3-[2-Chloro-4-(2,2-dimethyl-propyl)-phenoxy]-propoxy}-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid

Procedure

The title compound was prepared following the general procedure described in Example 1, Step 4 employing the chiral phenol prepared in Example 10, Step 2 and the iodide prepared in Step 1.

Sources & evidence

ORD record
ord-0c9b1cdfdc764fbb8e30af6667541ae8
Source dataset
uspto-grants-2009_04
Patent number
US07524882B2

Reaction notes

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