2-Ethyl-6-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester → 6-[3-(2-Chloro-4-trifluoromethoxy-phenoxy)-propoxy]-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid

HRID 2113166Notes

Reaction equation

HRID 2113166 reaction equation
C[O:2][C:3]([C:5]1([CH2:15][CH3:16])[CH2:9][C:8]2[CH:10]=[CH:11][C:12]([OH:14])=[CH:13][C:7]=2[O:6]1)=[O:4].I[CH2:18][CH2:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][C:23]=1[Cl:33]>>[Cl:33][C:23]1[CH:24]=[C:25]([O:28][C:29]([F:30])([F:32])[F:31])[CH:26]=[CH:27][C:22]=1[O:21][CH2:20][CH2:19][CH2:18][O:14][C:12]1[CH:11]=[CH:10][C:8]2[CH2:9][C:5]([CH2:15][CH3:16])([C:3]([OH:2])=[O:4])[O:6][C:7]=2[CH:13]=1

Participants

3

Reactant 2

HCID 113790512-Ethyl-6-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl esterHCID 69053655Benzene, 2-chloro-1-(3-iodopropoxy)-4-(trifluoromethoxy)-

Product 1

HCID 113856636-[3-(2-Chloro-4-trifluoromethoxy-phenoxy)-propoxy]-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid

Procedure

The title compound was prepared following the general procedure described in Example 1, Step 4, employing the phenol prepared in Step 2 and the iodide prepared in Example 3, Step 2.

Sources & evidence

ORD record
ord-dfa1ec8a14574874afc6c224d1b2752e
Source dataset
uspto-grants-2009_04
Patent number
US07524882B2

Reaction notes

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