2-tert-Butyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester → (R)-2-tert-Butyl-5-[2-(2-chloro-4-trifluoromethoxy-phenoxy)-ethoxy]-2,3-dihydro-benzofuran-2-carboxylic acid
Reaction equation
C[O:2][C:3]([C:5]1([C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:9][C:8]2[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:7]=2[O:6]1)=[O:4].[Cl:19][C:20]1[CH:25]=[C:24]([O:26][C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:22][C:21]=1[O:31][CH2:32][CH2:33]I>>[C:15]([C@@:5]1([C:3]([OH:2])=[O:4])[CH2:9][C:8]2[CH:10]=[C:11]([O:14][CH2:33][CH2:32][O:31][C:21]3[CH:22]=[CH:23][C:24]([O:26][C:27]([F:28])([F:29])[F:30])=[CH:25][C:20]=3[Cl:19])[CH:12]=[CH:13][C:7]=2[O:6]1)([CH3:18])([CH3:17])[CH3:16]Participants
3
Procedure
The title compound was prepared following the general procedure described in Example 1, Step 4, employing the phenol prepared in Example 21, Step 1 and the iodide prepared in Example 23, Step 1.
Sources & evidence
- ORD record
- ord-e9c9724a98264ee8a97cc311c18c65a3
- Source dataset
- uspto-grants-2009_04
- Patent number
- US07524882B2
Reaction notes
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