反应详情

To a solution of 4′-(2-benzylbenzofuran-3-yl)biphenyl-4-methanol (5.01 g, 12.7 mmol) in anhydrous acetonitrile (75 mL) was added dibromtriphenylphosphorane (5.45 g, 12.7 mmol) as a solid portionwise over 15 mins. The reaction was stirred for 2 hours (TLC control) and then poured into water (100 mL) and extracted with diethyl ether (3×100 mL). The combined extract was washed with water, brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo to afford the title compound as an off-white solid (4.98 g, 87%): 1H NMR (CDCl3, 300 MHz): δ 7.70 (2H, m, Ar-H), 7.63 (4H, m, Ar-H), 7.50 (3H, m, Ar-H), 7.30 (4H, m, Ar-H), 7.25 (4H, m, Ar-H), 4.57 (2H, s, CH2Br), 4.26 (2H, PhCH2).

1. extractionextracted with diethyl ether (3×100 mL)
2. extractionThe combined extract
3. washwas washed with water, brine
4. dry with materialdried over anhydrous MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo