4-Chloroaniline → HCID 10386765, compound

HRID 2113228Notes

Reaction equation

HRID 2113228 reaction equation
[C:1]([CH:4]([CH2:10][C:11](=O)[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[Cl:19])[C:5]([O:7][CH2:8][CH3:9])=[O:6])(=O)[CH3:2].[Cl:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1>C(O)C>[Cl:21][C:22]1[CH:28]=[CH:27][C:25]([N:26]2[C:11]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])=[CH:10][C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])=[C:1]2[CH3:2])=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 78124-ChloroanilineHCID 59671878HCID 59671878, compound

Product 1

HCID 10386765HCID 10386765, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

10 g of the compound obtained in step A) are dissolved in 45 ml of anhydrous ethanol in the presence of 4.1 g of 4-chloroaniline. The mixture is heated at the reflux point of the ethanol for 3 days. After evaporating off the solvent, the expected product is crystallized from an isopropanol/ethanol mixture. 12.5 g of white crystals are obtained.

Workup

  1. customAfter evaporating off the solvent
  2. customthe expected product is crystallized from an isopropanol/ethanol mixture

Sources & evidence

ORD record
ord-1fc74aacb7d44d94b4d1e27a7139e3b4
Source dataset
uspto-grants-2009_04
Patent number
US07524971B2

Reaction notes

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