Potassium Carbonate → HCID 67549712, compound

HRID 2113449Notes

Reaction equation

HRID 2113449 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[C:7]#[N:8].[CH3:11][C:12]1[N:13]=[CH:14][NH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:15]2[CH:16]=[C:12]([CH3:11])[N:13]=[CH:14]2)=[C:6]([CH:9]=1)[C:7]#[N:8]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 936535-Chloro-2-fluorobenzonitrileHCID 178418800HCID 178418800, compound

Product 1

HCID 67549712HCID 67549712, compoundYield 63%

Procedure

In analogy to example 5a, 5-chloro-2-fluoro-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 20 h at 90° C. After aqueous workup and crystallization from Ethyl acetate the title compound was obtained as a white solid (yield: 63%). MS: m/e=218.2 [M+H]+.

Workup

  1. customAfter aqueous workup and crystallization from Ethyl acetate the title compound

Sources & evidence

ORD record
ord-7813a3364f2940c4a965b882265c3713
Source dataset
uspto-grants-2008_10
Patent number
US07432256B2

Reaction notes

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