Potassium Carbonate → HCID 67549536, compound

HRID 2113451Notes

Reaction equation

HRID 2113451 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[C:4]#[N:5].[CH3:11][C:12]1[N:13]=[CH:14][NH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:10][C:7]1[CH:8]=[CH:9][C:2]([N:15]2[CH:16]=[C:12]([CH3:11])[N:13]=[CH:14]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 1235582,5-DifluorobenzonitrileHCID 178418800HCID 178418800, compound

Product 1

HCID 67549536HCID 67549536, compoundYield 41%

Procedure

In analogy to example 5a, 2,5-difluoro-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 20 h at 90° C. After aqueous workup and crystallization from Ethyl acetate the title compound was obtained as a white solid (yield: 41%). MS: m/e=202.3 [M+H]+.

Workup

  1. customAfter aqueous workup and crystallization from Ethyl acetate the title compound

Sources & evidence

ORD record
ord-0dbb7911ffde4fbfab33b75a52b15fe2
Source dataset
uspto-grants-2008_10
Patent number
US07432256B2

Reaction notes

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