Potassium Carbonate → HCID 67548761, compound

HRID 2113453Notes

Reaction equation

HRID 2113453 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([I:10])=[CH:6][C:3]=1[C:4]#[N:5].[CH3:11][C:12]1[N:13]=[CH:14][NH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].IC1C=CC(N2C(C)=CN=C2)=C(C=1)C#N>>[I:10][C:7]1[CH:8]=[CH:9][C:2]([N:15]2[CH:16]=[C:12]([CH3:11])[N:13]=[CH:14]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 27789282-Fluoro-5-iodobenzonitrileHCID 67549750HCID 67549750, compoundHCID 178418800HCID 178418800, compound

Product 1

HCID 67548761HCID 67548761, compound

Procedure

In analogy to example 5a, 2-fluoro-5-iodo-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 20 h at 90° C. Aqueous workup afforded a 1.9:1 mixture of the title compound and its regioisomer [5-iodo-2-(5-methyl-imidazol-1-yl)-benzonitrile] as a white solid (yield: 92%). MS: m/e=310.1 [M+H]+.

Workup

  1. customAqueous workup afforded

Sources & evidence

ORD record
ord-f2cca1e09af2497fb22882ebd1909d59
Source dataset
uspto-grants-2008_10
Patent number
US07432256B2

Reaction notes

Loading…