Potassium Carbonate → HCID 44203090, compound

HRID 2113461Notes

Reaction equation

HRID 2113461 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].[CH3:11][C:12]1[N:13]=[CH:14][NH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([N:15]2[CH:16]=[C:12]([CH3:11])[N:13]=[CH:14]2)[C:3]=1[C:4]#[N:5]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 695872-Chloro-6-fluorobenzonitrileHCID 178418800HCID 178418800, compound

Product 1

HCID 44203090HCID 44203090, compoundYield 73%

Procedure

In analogy to example 5a, 2-chloro-6-fluoro-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 16 h at 90° C. After aqueous workup and crystallization from Ethyl acetate/diisopropylether the title compound was obtained as an off-white solid (yield: 73%). MS: m/e=218.2 [M+H]+.

Workup

  1. customAfter aqueous workup and crystallization from Ethyl acetate/diisopropylether the title compound

Sources & evidence

ORD record
ord-d9d97938cad14ae6aca56d05b5a2c496
Source dataset
uspto-grants-2008_10
Patent number
US07432256B2

Reaction notes

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