反应详情

A mixture of 1.4 g (8 mmol) 1H-indole-5-carboxylic acid methyl ester and 1.28 g (9.6 mmol) N-chlorosuccinimid in 40 mL methanol was stirred at room temperature for 16 h. The mixture was evaporated to dryness and taken up in DCM washed with 1N NaHCO3 aq, dried with MgSO4, filtered and evaporated to dryness to yield 1.05 g (62%) of the title compound. MS(m/e): 210.1 (MH+).

1. customThe mixture was evaporated to dryness
2. washwashed with 1N NaHCO3 aq
3. dry with materialdried with MgSO4
4. filtrationfiltered
5. customevaporated to dryness