反应详情

To 125 ml of a dichloromethane solution of 6-nitrophtalide (8.0 g, 0.047 mol), bromine (8.25 g, 0.052 mol, 1.15 eq) and hydrogen peroxide (5.07 g of a 35% solution in water, equivalent to 1.77 of hydrogen peroxide, 0.052 mol, 1.15 eq) were added. The mixture was gently refluxed for 11 hours, then cooled down and concentrated by solvent evaporation. The aqueous layer was separated, and the organic phase washed with water before drying up (Na2SO4).

1. temperatureThe mixture was gently refluxed for 11 hours
2. temperaturecooled down
3. concentrationconcentrated by solvent evaporation
4. customThe aqueous layer was separated
5. washthe organic phase washed with water
6. dry with materialbefore drying up (Na2SO4)