Triethylamine → HCID 18660588, compound

HRID 2113492Notes

Reaction equation

HRID 2113492 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C@@H:6]1[C@H:10]([OH:11])[C@@H:9]([CH2:12][OH:13])[O:8][C@H:7]1[N:14]1[CH:21]=[C:20]([CH3:22])[C:18](=[O:19])[NH:17][C:15]1=[S:16].C(N(CC)CC)C.[F:30][C:31]([F:38])([F:37])[C:32](OCC)=[O:33]>CO>[F:30][C:31]([F:38])([F:37])[C:32]([NH:1][CH2:2][CH2:3][CH2:4][O:5][C@@H:6]1[C@H:10]([OH:11])[C@@H:9]([CH2:12][OH:13])[O:8][C@H:7]1[N:14]1[CH:21]=[C:20]([CH3:22])[C:18](=[O:19])[NH:17][C:15]1=[S:16])=[O:33]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9794Ethyl trifluoroacetateHCID 18660584HCID 18660584, compound

Product 1

HCID 18660588HCID 18660588, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2′-O-Aminopropyl-5-methyl-2-thiouridine is dissolved in MeOH and 5 equivalents of triethylamine are added followed by 10 equivalents of ethyl trifluoroacetate. The title compound is isolated after purification.

Sources & evidence

ORD record
ord-82ef2c45d9524548b32c90a4277532db
Source dataset
uspto-grants-2008_10
Patent number
US07432249B2

Reaction notes

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