Hydrochloric Acid → HCID 11584529, compound

Participants

Reaction Steps

0.5 mL of a saturated solution of hydrogen chloride in diethyl oxide is added at ambient temperature to a solution of 0.15 g (0.33 mmol) of 2-{4-[4-(3-trifluoro-methylphenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine (Example 3) in 5 mL of acetone. Precipitation is immediate. The suspension is stirred for 15 minutes, filtered and dried under a vacuum down to a constant mass. In this manner, 0.12 g of 2-{4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine dihydrochloride are obtained in the form of white solid.

Provenance & Evidence