Hydrochloric Acid → HCID 11584529, compound

HRID 2113542Notes

Reaction equation

HRID 2113542 reaction equation
[ClH:1].[F:2][C:3]([F:34])([F:33])[C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]3[CH:26]=[C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH:24]=[CH:23][N:22]=3)[CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1>C(OCC)C.CC(C)=O>[ClH:1].[ClH:1].[F:33][C:3]([F:2])([F:34])[C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]3[CH:26]=[C:25]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:24]=[CH:23][N:22]=3)[CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11584530HCID 11584530, compound

Product 1

HCID 11584529HCID 11584529, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

0.5 mL of a saturated solution of hydrogen chloride in diethyl oxide is added at ambient temperature to a solution of 0.15 g (0.33 mmol) of 2-{4-[4-(3-trifluoro-methylphenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine (Example 3) in 5 mL of acetone. Precipitation is immediate. The suspension is stirred for 15 minutes, filtered and dried under a vacuum down to a constant mass. In this manner, 0.12 g of 2-{4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine dihydrochloride are obtained in the form of white solid.

Workup

  1. customPrecipitation
  2. filtrationfiltered
  3. customdried under a vacuum down to a constant mass

Sources & evidence

ORD record
ord-f66aa3e05dca48118a34f972544994fa
Source dataset
uspto-grants-2008_10
Patent number
US07432269B2

Reaction notes

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