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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2113543Generated: October 30, 2026

Piperazine → 2-(Piperazin-1-yl)-6-(trifluoromethyl)benzonitrile

https://huagongshe.com/reaction/2113543

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperazineHCID 4837—
Reactant2-Fluoro-6-(trifluoromethyl)benzonitrileHCID 145613—
Solvent1,4-DioxaneHCID 31275—
Product2-(Piperazin-1-yl)-6-(trifluoromethyl)benzonitrileHCID 23120734—

Reaction Steps

A mixture of 3 g (15.8 mmol) of 2-fluoro-6-trifluoromethylbenzonitrile, 7.5 g (87 mmol) of piperazine and 24 mL of dioxane is heated at reflux for 5 hours.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07432269B2
Source datasetuspto-grants-2008_10
ORD IDord-7754f89a01cb46aaa98ef25c7b6ba433
Source noteuspto-grants-2008_10